PARADIGM arrêté en dec 2012 par défaut d'inclusion

We cannot rule out the possibility of a difference in survival going undetected due to early termination of the trial

Haddad R, O’Neill A, Rabinowits G, Tishler R, Khuri F, Adkins D, et al.

Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial.

Lancet Oncol. mars 2013;14(3):257‑64.